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By E. J. Ariëns (Eds.)

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It is resistant to metals and metal-complexing substances; the preferred electron donor is NADH (344). 3. Reactions Involving Hydrogen a. Introduction. In reactions involving hydrogen a transfer of hydrogen may be catalyzed from a substrate to an acceptor (cosubstrate) or vice versa. Often this type of oxidation-reduction reaction is found to be reversible. Three types of conversions involving hydrogen will be illustrated with a few examples. These reactions are dehydrogenation of hydroxyl to carbonyl, dehydrogenation of aldehyde to carboxyl, and the formation of a double bond.

Monooxygenases. i. Introduction. In this group are found those enzymes that catalyze the incorporation of one of the two atoms of atmospheric oxygen into the substrate. The other atom is reduced to water with the help of an electron donor. Because of the hybrid character of the monooxygenation Mason proposed the name: "mixed function oxygénation" (277). Studies with cell-free preparations of monooxygenases have led to an understanding of the diverse nature of the electron donor and cofactor requirements.

1. · This would be a good method to prepare special semisynthetic penicillins in order to test their antibiotic properties (131, 421). 2. Halogen Peroxidase An enzyme system derived from Caldariomyces fumago is capable of carrying out halogenations in vitro in the presence of a potassium halide and hydrogen peroxide. Halogenation of the 17a-position occurs with 16-ketoprogesterone and of the 16-position with 15-keto-l-dehydrotestololactone (304). The compound 9(1 l)-dehydroprogesterone is converted into 9a-Br-llß- 24 R.

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