Download Current Status of Diagnostic Cytology by L. G. Koss (auth.), Prof. Dr. med., Dr. rer. nat. Peter PDF

By L. G. Koss (auth.), Prof. Dr. med., Dr. rer. nat. Peter Pfitzer, Prof. Dr. med. E. Grundmann (eds.)

Progress in technological know-how is frequently promoted via a brand new approach. Diagnostic cytology, even though, built slowly over a complete century, in general in differentiating malignant from benign cells from a variety of tissues. The decisive step during this improvement was once the extensive research of 1 neighborhood­ ization via Papanicolaou: the appliance of cytology for screening within the box of gynecologic oncology made it an said method. hence, fabrics inves­ tigated sooner than have been established back on a bigger scale and new ones have been incorporated into this system. the opportunity of a wide-range software of this diag­ nostic technique, which incorporates a low hazard for the sufferer and is reasonable, attracted the experts of many fields. one of many difficulties which has resulted is the coordination of educating and caliber insurance for a wide team of individuals from varied fields and with varied pursuits and whose adventure in morphology varies. during this quantity basic difficulties of cytology are dis­ stubborn, as is the query "who is a clinical cytologist?" schooling and coaching are the subjects of the contributions via Coleman, Holzner, Jenny, Koss and Muller, hide­ ing the location within the eu neighborhood, Germany, Austria, Switzerland, and the us. a different contribu­ tion by way of Lange matters the location of cytotechnologists, paramedicals vital for cytologic screening programs.

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5, the gradual decrease in the fraction of diploid tumors with stage is nearly exponential as the modal suggests. The rapid initial increase in the fraction of tetraploid tumors and the more gradual decrease in later stages as the tumors are transformed into non-tetraploid aneuploid forms is correctly described. Finally, the accumulation of non-tetraploid aneuploid tumors with stage is also well predicted. The very good fit of this model to the clinical data is consistent with the transformation from low-grade to high-grade malignancy according to the 30 B.

0c DNA - Relative Values (Fig. 2). This difference in distribution strongly suggests the existence of two distinct types of aneuploid tumors in the bladder, also with different pathways of development as already discussed by Koss (1979) on the bases of bladder mapping and related histopathologic and clinic observations. 99 98 " Grade 3 / 9S / >90 :;::40 "' ]20 / / 10 / 60 . / . 0<; Relative Values Fig. 2. Left, cumulative frequency distribution of ploidy values of triploid to tetraploid aneuploid grade 3 tumors of the bladder plotted on a normal distribution graph paper.

The proportion of S-phase cells is significantly related with the stage of invasiveness of bladder carcinomas. Tumor Biology in Diagnostic Cytology 31 In prostate carcinomas, the exponential decrease of diploid tumor with tumor stage, the increase of tetraploid tumors to maximum at intermediate stages, and the exponential increase of aneuploid tumors with stages after some delay strongly support the concept of the continuous development of the prostate carcinoma according to a three-compartment system.

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