Download Alzheimer's disease and related disorders annual. / 2004 by Philip Scheltens MD PhD, Serge Gauthier, Philip Scheltens, PDF

By Philip Scheltens MD PhD, Serge Gauthier, Philip Scheltens, Jeffrey L. Cummings

content material: Innervation of Senile Plaques: A hyperlink among Amyloid and Neurofibrillary Pathology? B. Delatour, V. Blanchard, L. Pradier, and C. Duyckaerts Vascular components and Alzheimer's affliction, I. Skoog, D. Gustafson, and M. Sjogren The position of White subject Lesions in Dementia, L. Pantoni Subclassification of light Cognitive Impairment in examine and medical perform, S. Gauthier and J. Touchon Neuropsychiatric points of gentle Cognitive Impairment, T.J. Hung and J.L. Cummings Cognitive Rehabilitation in light Cognitive Impairment and Prodromal Alzheimer's affliction, M. van der Linden, A.-C. Juillerat, and X. Delbeuck scientific Trial layout within the Age of Dementia remedies: demanding situations and possibilities, E. Mohr, C.L. Barclay, R. Anderson, and J. consistent Ethics of analysis in Dementia, J. Karlawish Memantine: A Glutamate Antagonist for therapy of Alzheimer's ailment, R. Smith Doody, B. Winbald, and V. Jelic administration of Comorbidity in Alzheimer's sickness, R. Jones dietary Prevention in Alzheimer's affliction, O. Guerin and B. Vellas Index

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A cholesterol-rich diet results in an increased intensity of apolipoprotein E immunoreactivity in neurons,118 suggesting that elevated circulating levels of blood cholesterol may result in increased cerebral levels. Treatment of hypercholesterolemia Statins, such as lovastatin and simvastatin, are used to lower high cholesterol levels in humans. 120 Furthermore, guinea pigs treated with high doses of simvastatin showed a strong and reversible reduction of Abeta-42 and Abeta-40 levels in CSF and in brain homogenate.

97. Prince MJ, Bird AS, Blizard RA, Mann AH. Is the cognitive function of older patients affected by anti-hypertensive treatment? Results from 54 months of the Medical Research Council’s trial of hypertension in older adults. BMJ 1996; 312: 801–805. 98. Lithell H, Hansson L, Skoog I et al. The Study on COgnition and Prognosis in the Elderly (SCOPE). Principal results of a randomised double-blind intervention trial. J Hypertens 2003; 21:875–886. 99. van Bockxmeer F, Mamotte C. Apolipoprotein E4 homozygosity in young men with coronary heart disease.

Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: the Honolulu-Asia Aging Study. Diabetes 2002; 51:1256–1262. 129. Leibson C, Rocca W, Hanson V et al. Risk of dementia among persons with diabetes mellitus: a population-based cohort study. Am J Epidemiol 1997; 145: 301–308. 130. Curb J, Rodriguez B, Abbott R et al. Longitudinal association of vascular and Alzheimer’s dementias, diabetes, and glucose tolerance. Neurology 1999; 52: 971–975. 131. MacKnight C, Rockwood K, Awalt E, McDowell I.

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