Download Advances in Haemapheresis: Proceedings of the Third by H. J. Gurland (auth.), C. Th. Smit Sibinga, L. Kater (eds.) PDF

By H. J. Gurland (auth.), C. Th. Smit Sibinga, L. Kater (eds.)

The first foreign assembly on Apheresis was once held in Dyon in 1984. on the congress it grew to become transparent that either the technical and healing aspects built very quickly and it seemed fruitful to compile the investigators of the various nations operating within the parts. at the moment immunology had come to pervade many medical specialities, and hemapheresis, specifically plasmapheresis was once thought of a healing software in lots of immunological ailments which hitherto had proved to be deadly. New the way to establish definite antibodies and circulating immune complexes within the serum and the chances to take away them from the blood by means of numerous concepts (filtration, centrifugation, immunoabsorp­ tion) ended in a nearly out of control use of plasma alternate in various ailments. due to the fact then the technical probabilities of this system have been extra famous, as was once the effect of immunology on many ailments, and the chances to assemble particular parts for healing pur­ poses. but in addition we grew to become conscious of the constrained contributions of anec­ dotal info on successes or mess ups of apheresis as adjuvant therapy. hence overseas potential reports have been initiated to make serious evaluate attainable of apheresis in a variety of diseases.

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Extra info for Advances in Haemapheresis: Proceedings of the Third International Congress of the World Apheresis Association. April 9–12,1990, Amsterdam, The Netherlands

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3 kg battery could be transported independently. Asahi's approach to component separation was to integrate a hollow fiber filtration module into a modified blood collection set [26]. The inlet of the filtration module is connected to the outlet of the primary bag, which contains anticoagulant; the outlet ports of the module are connected to plasma and cellular collection bags. Following the collection of a whole blood unit, the bag set is disconnected from the donor. Again, hydrostatic pressure is used to move whole blood through the filter which separates plasma from cells.

To conserve energy and weight, pumps were excluded from the design. Whole blood is drawn from the donor by gravity intoa flexible reservoir located next to an inflatable bladder; both are contained within a rigid housing. When the reservoir is filled, the bladder is inflated forcing the whole blood through a filtration module; the plasma is collected in a separate container and the cells returned to the donor. In the initial model, the pressure required to inflate the bladder was obtained from a disposable C02 cartridge.

The operational characteriscis of its rotating membrane [5-7] suggested to us that it could be modified to provide plasma exchange in a manner which would compare favorably with the previously available methods [8]. Since the available data using this device was obtained with a polycarbonate based membrane, our first concern was to determine the sieving characteristics of the currently available polyamide membrane. In 1988, we documented the results of in-vitro and in-vivo studies which demonstrated that clinically important molecules, such as immunoglobulines and lipoproteins, were successfully removed with sieving coefficients which were essentially 1 [9].

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