By Andrei G. Pakhomov, Damijan Miklavcic, Marko S. Markov
"A mirrored image of the serious research of the results of electromagnetic fields on dwelling tissues that has taken position over the past a number of many years, this ebook discusses the theoretical and experimental proof and concerns the results of robust electromagnetic fields and/or electrical pulses and their significance in drugs and biology. The authors current the elemental options utilized in electroporation and the complicated tools for production of nanopores, highlighting their easy technology and medical functions. subject matters contain nano electroporation, vintage electroporaiton, experimental facts for electroporation of dwelling cells, and electroporation for melanoma and wound healing"--Provided by means of writer. learn more... content material: fundamentals of Electroporation actual Chemical idea of Membrane Electroporation and Electrotransfer of Biogenic brokers, E. Neumann and S. Kakorin Bioelectric impact of severe Nanosecond Pulses, K.H. Schoenbach precipitated Transmembrane Voltage-Theory, Modeling, and Experiments, T. Kotnik and G. Pucihar Electroporation: A assessment of uncomplicated difficulties in idea and scan, M.S. Markov Mechanisms of Electroporation in Lipid structures Electrodeformation, Electroporation, and Electrofusion of Cell-Sized Lipid Vesicles, R. Dimova Fluorescent equipment in assessment of Nanopore Conductivity and Their Computational Validation, M. Kotulska, W. Dyrka, and P. Sadowski Electroporation of Lipid Membranes: Insights from Molecular Dynamics Simulations, M. Tarek and L. Delemotte Nanoscale Restructuring of Lipid Bilayers in Nanosecond electrical Fields, P.T. Vernier Mechanisms of Electroporation of Cells Nanopores: a different Transmembrane Passageway in Electroporated Cells, A.G. Pakhomov and O.N. Pakhomova version of mobilephone Membrane Electroporation and Transmembrane Molecular delivery, D. Miklavcic and L. Towhidi Kinetics of Pore Formation and Disappearance within the telephone in the course of Electroporation, G. Saulis the heart beat Intensity-Duration Dependency for telephone Membrane Electroporation, D. Miklavcic, G. Pucihar, A.M. Lebar, J. Krmelj, and L. Towhidi Mechanisms of Electroporation in Tissues Drug-Free, stable Tumor Ablation via Electroporating Pulses: Mechanisms That Couple to Necrotic and Apoptotic telephone dying Pathways, A.T. Esser, K.C. Smith, T.R. Gowrishankar, and J.C. Weaver Gene Electrotransfer: From simple strategies to Preclinical purposes, J.-M. Escoffre, A. Paganin-Gioanni, E. Bellard, M. Golzio, M.-P. Rols, and J. Teissie Technical issues Modeling electrical box Distribution In Vivo, N. Pavselj, A. Zupanic, and D. Miklavcic options of Electroporation Pulse iteration and review of electrical Pulse turbines for mobile and Tissue Electroporation, M. Rebersek and D. Miklavcic new release of Ultrashort Pulses, J.F. Kolb Nanosecond Pulsed electrical box supply to organic Samples: problems and power ideas, A. Silve, J. Villemejane, V. Joubert, A. Ivorra, and L.M. Mir functions of Electroporation Translation of Electroporation-Mediated DNA supply to the hospital, L.C. Heller and R. Heller medical Electrochemotherapy: The Italian event, C.R. Rossi and L.G. Campana Tumor Blood Flow-Modifying results of Electroporation and Electrochemotherapy-Experimental facts and Implications for the treatment, T. Jarm, M. Cemazar, and G. Sersa lectrochemotherapy as a part of an Immunotherapy procedure within the remedy of melanoma, J. Gehl ombined electric box and Ultrasound: A Nondrug-Based technique for Tumor Ablation, P.F. Forde, C. Twomey, G.C. O' Sullivan, and D. M. Soden mixed Modality remedy: Electrochemotherapy with Tumor Irradiation, G. Sersa, S. Kranjc, and M. Cemazar Irreversible Electroporation in drugs, B. Rubinsky meals and Biomaterials Processing Assisted via Electroporation, N. Lebovka and E. Vorobiev In Vivo Electroporation: an incredible harm Mechanism in electric surprise Trauma, I. Barakat, J. Gallaher, H. Chen, and R.C. Lee Index summary: Reflecting the serious examine of the results of electromagnetic fields on dwelling tissues that has taken position through the years, this identify summarizes the experimental findings and theories relating to permeabilization of biomembranes by way of pulsed electrical fields. it really is meant commonly for biomedical and actual scientists, engineers, and clinicians. learn more...
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Extra info for Advanced electroporation techniques in biology and medicine
Besides entering a new field of bioelectrics by moving into the subnanosecond temporal range, there is a practical reason for entering this new field. It is the possible use of antennas as pulse delivery systems. , 2006) requires that the electrodes are brought into close contact with the treated tissue. This limits the application to treatments of tissue close to the surface of the body. The use of antennas, on the other hand, would allow one to apply such electric fields to tissues (tumors) that are not easily accessible with needles.
25, 284–292. , 2001, Intracellular effect of ultrashort electrical pulses, J. , 22, 440–448. , 2002, Bioelectrics—New applications for pulsed power technology, IEEE Trans. , 30, 293–300. , 2004, Ultrashort electrical pulses open a new gateway into biological cells, Proc. IEEE, 92, 1122–1137. , 43(8), 20–26. , Pakhomov, A. , 2007, Bioelectric effects of nanosecond pulses, IEEE Trans. Dielect. Electr. , 14, 1088–1119. , 2008, The effect of intense subnanosecond electrical pulses on biological cells, IEEE Trans.
2009b). Imaging is based on the measurement of changes in the complex permittivity of tissue and may complement methods based on the measurement of other physical parameters, such as X-ray computed tomography (CT), magnetic resonance imaging (MRI), and ultrasound. , 2002) and can therefore be easily differentiated from normal tissue. In such an imaging system, the electromagnetic waves are focused on a target inside the body. The scattered signal contains information on the dielectric properties and the geometry of the target and allows its identification through an inverse scattering method.